Key Results:
BACA JUGA:Monas Sebagai Simbol Identitas dan Sejarah Indonesia
Superior internalization, payload delivery, and spheroid penetration to other FRα-targeted multi-specific antibodies.
Bystander active payload drives activity in settings with heterogeneous FRα expression.
Well-tolerated, with a highest non-severely toxic dose of 60 mg/kg in non-human primates.
Screening novel format antibodies to design bispecific ADCs that address target heterogeneity
Abstract: 2052
Session Category: Experimental and Molecular Therapeutics
Session Title: New Technologies
Inter-patient and intra-tumoral target expression heterogeneity is an obstacle in the design of ADCs that target a single tumor associated antigen (TAA). While bystander active payloads mitigate intra-tumoral target heterogeneity, bispecific ADCs that target two different TAAs independently provide an additional approach to overcome limitations associated with the expression profile of any single target antigen. Critical to this bispecific ADC approach however is identification of the optimal bispecific antibody format suited for payload delivery to two independent tumor antigens. To address this challenge a novel design and screening approach of bispecific ADCs was employed, using FRα and NaPi2b as an exemplary target pair, independently expressed across various cancer types.
Key Results: